Researchers from the University of Alabama at Birmingham conducted an observational study to find out how the cellular immune response changes in patients with Covid-19.
From blood samples from 46 patients hospitalized with Covid-19 and 39 people with SARS-CoV-2 who were treated at home, the authors isolated specific groups of immune cells and analyzed markers. their surface effect. Data were compared with those in a healthy control group. It turns out that many Covid-19 patients have impaired immune cells due to the disease.
The authors note that impaired immune cells are less able to resist secondary infection and hinder the development of a fully protective immunity to Covid-19.
The scientists also analyzed the changes by continually observing the changes of surface markers in the samples and by directly comparing the frequency of these markers between the first blood test and the second time.
The study included in-depth description of the activation and depletion phenotype of CD4 + T-cells, CD8 + T-cells and B-cells and T-cells of both groups of patients, respectively. signs of activation and cell decline during the first two months of illness, while markers of activation and impairment increased over time in non-hospitalized individuals.
These results indicate the nature of the changes in the adaptive immune system in Covid-19 and show the longer-term effects of impaired immunity, including: both for SARS-CoV-2 “.
The results of this study were published in the Journal of Clinical Investigation.